Personal Statement
My background is in clinical medicine with certifications in both Internal Medicine and Anesthesiology, which I continue to practice. I have also been very active in basic science and clinical investigations in cardio-pulmonary physiology and biomedical engineering. In this regard, my focus has been on the control of blood gases via the lungs. Dr. Jim Duffin and I run an animal laboratory, a human laboratory and supervise the development of novel customized biomedical technology. This has led to work in developing the science, and reduction to practive of novel respiratory Fick cardiac output and the precise control of blood gases as cerebrovascular stimuli (using BOLD MRI as measures of the hemodynamics). I am one of the originators of the sequential gas delivery system (RespirAct™) and the use of automated blood gas control. I have also joined with Dr. David Mikulis and his laboratory where I focus on the interplay between MRI signal generation and the physiology of cerebral vasculature, and methods to normalize CVR data to make it compatible between centers. I have also collaborated in studies with 5 Canadian, 4 U.S., and 2 European laboratories.
Keywords: cerebrovascular reactivity, cardiac output,breating circuit design, carbon monoxide poisoning, life support systems
Keywords: cerebrovascular reactivity, cardiac output,breating circuit design, carbon monoxide poisoning, life support systems
Key Publications
- Fisher JA, Iscoe S, Duffin J. Sequential gas delivery provides precise control of alveolar gas exchange. Respir Physiol Neurobiol 2016; 225:60-69.
- Sobczyk O, Crawley AP, Poublanc J, Sam K, Mandell DM, Mikulis DJ, Duffin J, Fisher JA. Identifying Significant Changes in Cerebrovascular Reactivity to Carbon Dioxide. AJNR Am J Neuroradiol 2016;
- Sobczyk O, Battisti-Charbonney A, Poublanc J, Crawley AP, Sam K, Fierstra J, Mandell DM, Mikulis DJ, Duffin J, Fisher JA. Assessing cerebrovascular reactivity abnormality by comparison to a reference atlas. J Cereb Blood Flow Metab 2015; 35:213-20.
- Poublanc J, Crawley AP, Sobczyk O, Montandon G, Sam K, Mandell DM, Dufort P, Venkatraghavan L, Duffin J, Mikulis DJ, Fisher JA. Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus. J Cereb Blood Flow Metab 2015;
- Klein M, Minkovich L, Machina M, Selzner M, Spetzler VN, Knaak JM, Roy D, Duffin J, Fisher JA. Non-invasive measurement of cardiac output using an iterative, respiration-based method. Br J Anaesth 2015; 114:406-13.
- Fisher JA, Iscoe S, Fedorko L, Duffin J. Rapid elimination of CO through the lungs: coming full circle 100 years on. Exp Physiol 2011; 96:1262-1269.
- Katznelson R, Van RA, Friedman Z, Wasowicz M, Djaiani GN, Fedorko L, Minkovich L, Fisher JA. Isocapnic hyperpnoea shortens postanesthetic care unit stay after isoflurane anesthesia. Anesth Analg. 2010; 111:403-408.
- Balaban DY, Fisher JA. The in vivo oxyhaemoglobin disociation curve at sea level and high altitude. In: Institute of Medical Science, University of Toronto; 2009.
- Ito S, Mardimae A, Han J, Duffin J, Wells G, Fedorko L, Minkovich L, Katznelson R, Meineri M, Arenovich T, Kessler C, Fisher JA. Non-invasive prospective targeting of arterial P(CO2) in subjects at rest. J.Physiol 2008; 586:3675-3682.
- Slessarev M, Han J, Mardimae A, Prisman E, Preiss D, Volgyesi G, Ansel C, Duffin J, Fisher JA. Prospective targeting and control of end-tidal CO2 and O2 concentrations. J Physiol 2007; 581:1207-1219.
Contact:
Email: [email protected]
Webpage: http://www.uhnresearch.ca/researcher/joseph-fisher Social Media: Google Scholar |