Diffenrence between Gen III RespiAct™ and Gen IV RespiAct™
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Gen IV RespirAct™
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Mode of action
Initialization parameters adjustment Accuracy of targeting Time to set up and begin patient test Subject comfort (and tolerance of hypercapnia) Breathing circuit Ventilated subjects Size of box in control room Safety |
Prospective targeting; User has to interrupt sequence to adjust or start again if initial targeting is off.
User has to be trained to adjust machine and arrive at suitable baseline initialization of physiologic parameters which vary from subject to subject Machine was prospective only. If targets not met or drift occurred the user had to readjust parameters ‘on the fly’ or stop study and restart with new parameters. Effective sequential gas delivery (required for accurate and precise targeting) is limited by mechanical factors 20 min + Tolerance reduced by slight inspiratory resistance, warmth and moisture of rebreathed gas or dryness of compressed gas Manifold with 3 valves and 2 bags; cumbersome; risk of hypoxia if inspiratory gas not connected. No (requires a special improvised circuit. Size of desktop computer Requires operator training to avoid possibility of hypoxia |
Automatically optimizes algorithms for prospective targeting. New method of adjusting inspired gas concentrations in real time during inspiration resulting in very robust targeting. Monitors end-tidal gas in real time and feeds back to automatically adjust prospective algorithm.
Machine automatically measures initialization parameters. It tests these measurements with initial targeting and automatically makes all adjustments on the fly. If Machine’s initialization parameters are off, Machine monitors results and feeds back adjusted initialization parameters to prospective algorithm. Sequential gas delivery is virtual, digital, and perfect. Targeting precision is very precise, and limited only by accuracy and precision of sensors. ~5 min (target) · Zero inspiratory resistance · Inhaled gas has temperature and moisture of room air: subjects are, surprisingly, much more comfortable and tolerant of hypercapnia A 15 x 4 cm cm manifold attached to the mask and open to air. If no gas flow, subject breathes air YES. Just interpose small manifold between endotracheal tube and ventilatory Y piece. Reduced to about a third. fails safe to breathing room air. NO Possibility of hypoxia. |