Gen IV RespirAct™ Part IV - Deliverance
Dear Colleagues,
Some of you may have been following this saga through the several stages where we had just diagram, then breadboard prototypes of components, then breadboard prototypes that actually did something, then actual device components, and now complete device with software. See the attached pictures and story of delivery of the first RespirAct™ RAMR (AKA Gen 4) to TWH, where this all started in about 1997 or 1998 when David Mikulis phoned me and said “I have a student here that says that you may be able to control CO2 during MR scanning… I said “sure…” (who was I to blow against the wind?) We focused mainly on brain CVR; but as we worked on this, additional applications were emerging such as using hypercapnia as a coronary stress (see Yang R, Dharmakumar R, J Nucl Med 2017). The RespirAct™ is technically just as astute at generating hypoxia as controlling CO2. This has been shown to be valuable for acclimatization, healing of hearts, spinal cords, brains after cardiac arrest, lungs with ARDS and others. As such please make your possession of a RespirAct™ known and available to colleagues in your institutions. These are still early days. You are the pioneers. Joe Joseph A. Fisher M.D. FRCP(C) Department of Anesthesiology, University Health Network Professor, Faculty of Medicine, University of Toronto, Candada Senior Scientist, Division of Advanced Diagnostics, Cardiovascular, Toronto General Research Institute Chief Scientist, Thornhill Research Inc. http://www.uhnresearch.ca/researchers/profile.php?lookup=1834 http://scholar.google.com/citations?hl=en&user=eLMnUQsAAAAJ&cstart=160&view_op=list_works&gmla=AJsN-F4XpTPTz8Zd6D58uDpfEWXtvhbjq4JDQLi-O8pHrzicYbPpVK6B2r5utL19En07wUUSEOixEZYxAWlY0jEx_qBJLzr1HtoeZauQIvGy4iLHcDGIUKSaG6hkSbrdwRxQb-2eLuaM Address: Thornhill Research Inc. Toronto General Hospital: 210 Dundas St. W. Suite 200 Dept. of Anesthesiology 3EN Toronto, ON 200 Elizabeth St. Canada, M5G 2E8 Toronto, ON Fax: 416 597 1330 Canada Email: [email protected] |
RespirAct™ Chapter 4: Deliverance of RAMR* |
Installation of Gen 4 RespirAct™ in 3T suite, Toronto Western Hospital February 15, 2017.
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The scientists, designers, engineers, regulatory people, assemblers and technicians, have certainly put our all into this device to take it from concept to shipping in about a year and a half; while continuing to follow a quality system under ISO 13485. What the RespirAct™ is capable of doing and how it does it are unique in the world. Period. It is designed to be automated, easy to use, precise, accurate, reproducible and safe. OK, I get the argument that you don’t need a Lamborghini if you intend to deliver pizza. But I hope we are delivering this Lamborghini exclusively to those who intend to take this baby to the races! Now that gas control is fully automated the stimulus can be, for the first time, consistent and reproducible in an institution and between institutions. The capability of producing consistent stimuli begs for joining our data together into a unique exclusive database. I will be back to you on that once you are set up and running. We are going to fasten our seat belts and are looking forward to your abstracts, talks and papers showing great data that is going to take the CVR world by storm. Sincerely, Joe |